Gestational Trophoblastic Disease and Gestational Trophoblastic Neoplasm - An Experience at Tertiary Care Hospital

Authors

  • Shakira Perveen
  • Shazia Jabbar
  • Shafia Nizar

DOI:

https://doi.org/10.58397/ashkmdc.v23i3.74

Keywords:

Gestational trophoblastic disease, neoplasm, choriocarcinoma, suction evacuation.

Abstract

Objective: To determine the frequency of gestational trophoblastic diseases and gestational  tropho-  blastic neoplasm, its risk factors and prognosis.

Methods: This was a descriptive,  cross-sectional  study  conducted  at  Civil  Hospital,  Karachi  from  March 2015 to September 2015. All cases of gestational trophoblastic disease after necessary inves- tigations like tumour marker b-hCG, ultrasound with classical picture of "bunch  of  grapes"  or  "snow  storm" pattern and X-ray chest (for lung metastases) under went suction evacuation.  In  all  cases  specimen was sent for histopathology to confirm gestational trophoblastic disease. After primary treat- ment, cases were followed with  b-hCG till complete remission was achieved. During follow-up, cases     were labelled as gestational trophoblastic neoplasm on the basis of International Federation of Gyne-  cology and Obstetrics (FIGO) criteria. After risk scoring on World Health Organization (WHO) criteria, chemotherapy was given.

Results: Out of 497 pregnant ladies, 40 were cases of gestational trophoblastic disease (8.05%). Frequency/obstetric case was 1.7% and frequency/delivery was  2.1%.  Out  of  40  cases  13  (32.5%)  were cases of gestational trophoblastic neoplasm. Out of 13 cases  of  gestational  trophoblastic  neo-  plasm 9 (69.23%) were labelled as low-risk and 4 (30.76%) as high-risk cases. All cases  achieved  complete remission. One case of high-risk group expired.

Conclusion: All women with gestational trophoblastic disease must  be  followed  as  per  recommenda- tion with serum b human chorionic gonadotropin  measurement  until  the  levels  are  undetectable,  for early diagnosis and optimum treatment of gestational trophoblastic neoplasm.

Author Biographies

Shakira Perveen

Dow University of Health sciences

Shazia Jabbar

Dow University of Health sciences

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Published

2018-09-30